Amedeo, or "Dedo," Modigliani was the youngest of four children born to Jewish parents, Flaminio and Eugenia, in Livorno, Italy, home to a large Jewish community. Shortly before his birth, the family businesses had fallen onto hard Modiglianitimes, forcing the Modiglianis to declare bankruptcy. Amedeo's timely arrival may have resulted in the rescue of many valuable heirlooms; according to family legend, soldiers were forced to avoid Eugenia in childbirth as they came to repossess the furniture, in accordance with an old Italian custom that forbade the seizure of any possessions in the bed of a woman in labor.
After being diagnosed with tuberculosis in 1901, Modigliani recuperated in southern Italy with his mother. Visits to the museums in Naples, Rome, Florence, and Venice familiarized him with classical Italian painting and sculpture, fueling his enthusiasm for the fine arts. After their return to Livorno, he convinced his mother to allow him to move to Florence, where he studied figure drawing at the Scuola Libera di Nudo. Possibly inspired by his admiration for Michelangelo, he moved to Pietrasanta in 1903 to devote his time to sculpture, but found his strength insufficient for the strenuous and time-consuming stone-carving process.

In Florence, Modigliani became acquainted Madamwith Manuel Ortiz de Zarate, an artist who had worked with the Impressionists. Intrigued by Zarate's descriptions of Paris and the avant-garde, Modigliani decided to pursue his ambitions there, but his mother encouraged him to stay in Florence. Restless for new opportunities, Modigliani moved to Venice and enrolled in the Scuola Libera di Nudo at the Istituto di Belli Arti, which he found overly traditional in its curriculum. He discovered a preference for art-making amid the atmosphere of the local bars and cafes, where he was introduced to illicit substances. Growing increasingly dissatisfied with the art scene in Italy, his mother finally allowed him to move to Paris in 1906.

As Modigliani settled into Paris, he enrolled in housethe Académie Colarossi and spent the first few months visiting area galleries and museums. He was soon absorbed into the Bateau Lavoir circle, which included Juan Gris, Max Jacob, Pablo Picasso, and André Salmon, among other well-known art and literary figures. Searching for an innovative style that could compete with those practiced by the Parisian avant-garde, Modigliani concentrated on painting. Works from this period show a high regard for the Post-Impressionists. Head of a Woman Wearing a Hat (1907) makes use of a curvilinear style that is characteristic of Art Nouveau, but also exhibits the influence of Henri de Toulouse-Lautrec in the tilt of the woman's shoulders and the thoughtful, expressive face, revealing Modigliani's early interest in representing psychological states.

In 1917, Modigliani met Jeanne Hebuterne, a young art student from the Académie Colarossi. The two fell in love, and Hebuterne later became his common-law wife.Jeanne Zborowski, who had committed himself to supporting Modigliani's work, hoped that their relationship would provide both a new source of inspiration for Modigliani's portraiture and a measure of stability for the artist that would help temper Modigliani's dissolute lifestyle. Although his alcohol and drug consumption remained virtually unchanged during their time together, the portraits of Hebuterne reflected the artist's newfound sense of relative tranquility. In 1918, she gave birth to a daughter, named for her mother. New familial responsibilities, combined with his professional obligations to Zborowski, spurred Modigliani to increase productivity despite his fading health. A self-portrait from 1919 suggests a sense of calm and confidence in his work, which afforded him some measure of peace toward the end of his life. Yet, the artist's health ultimately gave way, with Modigliani succumbing to tubercular meningitis the following year.

Although his works were not commercially successful during his lifetime, they Leopoldbecame increasingly popular after his death. Modigliani is now among the celebrated artists of the twentieth century. While not closely associated with any one particular early-twentieth-century "ism," Modigliani arrived at a signature style that fused aspects of contemporary European artistic developments such as Cubism with non-Western art forms like African masks. His portraits and nudes overturned the conventions of both genres, uniquely combining innovative formal experimentation with probing candor and psychological insight, and earning the admiration of Modigliani's artistic contemporaries such as his close friend and fellow Ecole de Paris artist, the painter Chaim Soutine.